It is a slender, laticiferous, twining, sometimes prostrate or semierect shrub call us. The leaves vary much in size and shape, some being linear and acute, others broadlanceolate, and others again oval or ovate. Glucosidase inhibition, antioxidant, and neuroprotective activity of methanol extracts and its derived fractions of b. The antioxidant potency and phenolic content of bemidesmus free phenolic and bound phenolic fraction click here to view. Hemidesmus indicus benefits, usage, dose, side effects. Though the extracts of these plants were found to be antimicrobial in nature and have the potential to be used in clinics, the mechanism of action of is not reported. Hemidesmus indicus is an important medicinal plant and extensively used in ayurvedic and unani system of medicine. Hemidesmus indicus definition of hemidesmus indicus by.
Antioxidant and antihyperlipidemic activity of hemidesmus. Enhancement in the absorption of water and electrolytes from rat intestine by hemidesmus indicus r. Pdf in vitro antioxidant and antithrombotic activity of hemidesmus. A special kind of milky latex is found in the climber. Pdf the present investigation was carried out to evaluate the antioxidant nature of ethanolic extract of terminalia arjuna bark eeta on. Evaluation of phytochemical composition and antioxidative. Year 2001 isbn 0849329299 description a very detailed book on some of the key ayurvedic herbs, giving both technical and nontechnical information on each plant. Pdf the methanolic extract of hemidesmus indicus l r. The present study suggests that hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract, as well as in. Encapsulated poly lactide coglycolide plga nanoparticles. The present study was conducted to evaluate antimicrobial, cytotoxic and antioxidant activities in 85% ethanol and hot water extracts of root and leaves of h. The present study was undertaken to evaluate the effect of terpenoidal fraction of the roots of hemidesmus indicus roots tfhi on several in vitro antioxidant and antiacne activity. Morphological and phytochemical characterisation of different accessions of hemidesmus indicus l. The root bark also possess antioxidant activity ravishankara et al.
Extensive epidemiological and clinical studies revealed that alzheimers disease ad and type 2 diabetes mellitus t2d are most likely to appear simultaneously in aged people as t2d is a major risk factor for ad. Pharmacological activity antioxidant activity in the study conducted by ravishankara and coworkers methanolic extract of hemidesmus indicus roots showed a concentrationdose dependent inhibition of 1, 1diphenyl2picryl hydrazyl dpph radical, superoxide radicals and moderate nitric oxide scavenging activity. Indian sarsaparilla gymnema sylvestre hemidesmus indicus. Periplocaceae is being used widely in ayurvedic medicine. Cleavage of the ester linkage generated a fragment at mlz 129. In ayurveda system of medicine, it is widely used in the treatment of oligospermia, gastritis, anorexia, menorrhagia etc. Antioxidant and antihepatotoxic activities of hemidesmus indicus r.
A number of indian medicinal plants have been used for thousands of years in a traditional system of medicine. Pdf in vitro antioxidant and antithrombotic activity of. Hie was analyzed by lcms to determine its phytochemical composition. Angiosperm diversity assessment of chitrakootthe legendary place of vindhyan range, india journal of economic and taxonomic botany 38. Hemidesmus indicus sariva consists of root of hemidesmus indicus linn. Request pdf antioxidant activity of roots of hemidesmus indicus the antioxidant property of roots of hemidesmus indicus l. Hemidesmus indicus belongs to apocynacea dogbane family. The roots have a sweet smell like camphor hence known as karpuri. Media in category hemidesmus indicus the following 56 files are in this category, out of 56 total. The root extracts of hemidesmus indicus in different ratios of petroleum ether and ethyl acetate, tests have shown significant zone of inhibition to all these microorganisms viz.
Although other species of this variety has been reported for its standards7 this has been the complete pharmacognostic validation of this variety which may be used for formulation development in future. Shahid chatha, shahzad ali, department of applied chemistry. Hemidesmus indicus is a pharmacologically important plant. Br article pdf available in journal of ethnopharmacology 8723. Antioxidant and free radical scavenging properties of.
The literature has already documented the antioxidant and hepatoprotective value of flavonoid and coumarinolignans33. Cell culture derived hemidesmus indicus in the prevention of hypercholesterolemia in normal and hyperlipidaemic rats. The present work is based on the standardization of hemidesmus indicus root by pharmacognostically as per who guidelines. Frontiers mechanism of antibacterial action of the. Antinociceptive activity of alcoholic extract of hemidesmus indicus r. Preliminarily phytochemical screening and in vivo safety. It is a climbing plant that grows almost all over india. It is an effective antiinflammatory, direutic and vulnerary. Antimicrobial activity of hemidesmus indicus, ficus. Thus, it appears that the hepatoprotection offered by h. The change in the absorbance produced at 517nm has been used as a measure of antioxidant activity. Hemidesmus indicus is used to make beverages and also used in traditional medicine. Or you can apply the milky exude of the plant mixed with honey.
Diversity and biological activities of fungal root endophytes of hemidesmus indicus l. The bioactive and therapeutic potential of hemidesmus. Indian sarsaparilla, which are commonly known as anantamul, are used extensively for the treatment of a variety of ailments in the indian ayurvedic system of medicine. In carbontetrachloride induced hepatic challenge in rats, a remarkable elevation of lipid peroxidation and a decrease in liver. Antimicrobial activity, ficus bengalensis, hemidesmus indicus, pterocarpus marsupium roxb, saponins, tannins, saponins medicinal plants have been used as an exemplary source for centuries as an alternative remedy for treating human diseases because they contain numerous active constituents of therapeutic value 1. The amount required for 50% inhibition of lipid peroxide formation was 217. The aqueous extract of hemidesmus indicus was showed significant antioxidant activity than that of standard. Roots 2391 23 21 19 17 15 24 3j 29 28 1 rh 1a r me 0 or a. Asclepiadaceae is a well known drug in ayurveda system of medicine. Simarouba glauca also called bitter wood, paradise tree and lakshmi taru 24, belongs to order sapindales, family simaroubaceae, genus simarouba and species glauca. Hemidesmus indicus, sariva, asclepiadaceae, indian sarsaparilla created date.
P antioxidant activity of hmba occurs by quenching the lipid oxidation and restoring the gsh level. The present study is designed to investigate antiinflammatory effect of ethanolic extract of hemidesmus indicus eehi on rats and mice. Hemidesmus indicus possesses phytochemicals responsible for its antioxidant and choleretic activity. Title handbook of ayurvedic medicinal plants publication author kapoor. Anantmoola, hemidesmus indicus, indian sarsaparilla, sariva. The total phenol content was calculated using gallic acid as standard. It is concluded that the ointment containing the methanolic extract and not the aqueous. Assessment of antioxidant potentials of free and bound phenolics of. Therefore, development of potential multifunctional agents for dual therapy of ad and t2d has received much attention. Hemidesmus indicus protects against ethanolinduced liver toxicity. In the present study, antioxidant activity of methanolic extract of h. In ayurveda, it has been used medicinally to treat stomach problems, to cure rashes and to calm the mind and induce trance states and deep meditation. Diversity and biological activities of fungal root. The extract decreased the number of acetic acidinduced abdominal constrictions in mice and the values were found to be significant at doses level tested fig.
Antioxidant and antihyperlipidemic activity of hemidesmus indicus ajp, vol. The in vitro antioxidant potential of tfhi was evaluated by various antioxidant assays, including dpph radical scavenging, superoxide radical scavenging in riboflavinlight nbt, and nitric oxide no. Further, preliminary phytochemical analysis and tlc fingerprint profile of the extract was established to characterize the extract which showed. Hemidesmus indicus, phytochemical constituents, pharmacological actions, toxicity.
University of baroda, vadodara 390002 gujarat, india 2 radiology department, ssg. Anantamul, sariva, indian sarsaparilla is a wellknown indian plant 1012. Frap assay of aqueous extracts of hemidesmus indicus. Hemidesmus indicus, indian sarsaparilla, is a species of plant that is found in south asia. Studies on steroids in cultured tissues and mature plant of h.
Hemidesmus indicus is given as an emetic, and sometimes it is given in place of ipecacuanha, from which syrup of ipecac, a common emetic, is made. Bioactive components and antioxidant properties of terminalia arjuna l. Asclepiadaceae roots was found to inhibit lipid peroxidation and scavenge hydroxyl and superoxide radicals in vitro. Academic sciences asian journal of pharmaceutical and. It has been used to treat chronic rheumatism, kidney and skin disorders and constitutional debility. Medicinal plants are being widely used, either as single drug or in combination in health care delivery system. Phytochemical profiling and in vitro screening for. Conversely, the antioxidant activity of hemidesmus indicus, cichorium intybus, withania somnifera, ocimum sanctum, mangifera indica, and punica granatum, as determined by.
The herbal extract has promote the release of igg by lymphocytes and also the ada activity kainthla r p, kashyap effect of hemidesmus indicus anantmool extract on igg production and adenosine deaminase activity of human lymphocytes in vitro. Antibacterial activity of the root extracts of hemidesmus. Hair growth, alopecia, hair fall take 2 grams hemidesmus indicus root powder, 23 times a day with water. The in vitro experiment by the disc diffusion method established that hemidesmus indicus root extracts posses a bioactive compound, which inhibits the growth of the microorganisms. Antioxidants react with dpph and convert it to 11diphenyl 2picryl hydrazine. Hemidesmus indicus, commonly known as anantmul, possesses various pharmacological activities including antiinflammatory activity. Hemidesmus free phenolic fraction hdfp and hemidesmus bound phenolic fraction hdbp have been isolated from h. At other times the herbs leaves are used medicinally for the treatment of whooping cough, bronchitis and asthma.
Common names are anantamula, ananthamoola, east indian sarsaparilla, false sarsaparilla. In this study, we examined the effects of its ethanolic root extract on experimental liver damage in order to evaluate its hepatoprotective effects against hepatotoxicity induced in rats by ethanol at a dosage of 5 gkg body weight for 60 days. Antinociceptive activity of alcoholic extract of hemidesmus. The antioxidant properties of free and encapsulated root extract were determined by dpph, superoxide and hydroxyl radical scavenging assays. Effect of 2hydroxy 4 methoxy benzoic acid isolated from. Evaluation of antioxidant properties of root bark of. Cytotoxic effects of a decoction of nigella sativa, hemidesmus indicus and smilax glabra on human hepatoma hepg2 cells. Phytochemical investigation of hemidesmus indicus r. Nov 14, 2005 the extract of hemidesmus indicus at doses of 25, 50 and 100 mgkg, showed antinociceptive activity in all the models for nociception and the effect was found to be dosedependent. Antibacterial activity, hemidesmus indicus, medicinal plants.
The ethanolfed rats showed significantly elevated liver marker enzyme activities, lipid peroxidation levels and reduced antioxidant levels as. Research article open access phytochemical profiling. However, their properties are still not fully understood and deserve further theoretical and experimental investigations. Even though hemidesmus indicus was reported to be useful in a many ailments, scientific evaluation of the plant was not reported for its antiasthmatic activity. The leaves are very slender, smooth and oval shaped, closely resembling blades of grass, and they maintain a uniform shiny dark green color throughout the year. Medicinal uses of anantmool or indian sarsaparilla bimbima. Gum diseases, tooth problems crush the leaves of the plant and put under the teeth. Buchanania axillaris, hemidesmus indicus and rhus mysorensis. The history of its medicinal importance dates back to ancient times. The aim of the study was to evaluate the antioxidant, hypoglycaemic and hypolipidemic potential of methanolic extract of roots of hemidesmus indicus hie in streptozotocin stz induced diabetic mice. Hemidesmus indicus is known in ayurvedic medicine as sugandi, and it has been valued for its medicinal properties for almost a thousand years.
Studies have also reported larvicidal potential of hemidesmus indicus root extracts 10. The present study was designed to investigate the ameliorative potential of different extracts of hemidesmus indicus to experimental highfat diet in wistar rats, and their possible mechanism of action. Alleviates contamination of skin, skin diseases, itches, boils, purifies blood. The degree of discoloration indicates the scavenging potential of the antioxidant extract. Apr 14, 2015 latin binomial gymnema sylvestre hemidesmus indicus common name indian sarsaparilla, nunnari, mesasrngi, cowplant family asclepiadaceae 1 parts used root, bark, stem 1, leaf 8 qualities bitter 9 active constituents triterpenoidic saponins, hypoglycaemic activity 3 gymnemic acids, acidic glycosides, and anthroquinones 9, gymnema saponins, polypeptide, gurmarin 10, resins. Asclepiadaceae is a climbing plant, with twining, woody, slender stems, and opposite, petiolate leaves, which are entire, smooth, shining, and of a firm consistence.
Antioxidant activity of roots of hemidesmus indicus. Ayurvedic plants buchania axillaris, hemidesmus indicus, pavetta indica and ochna obtusa to develop potent agents for dual therapy of both ad and dm. Wound healing activity of hemidesmus indicus formulation ncbi. Pdf antioxidant activity of leaf extracts of hemidesmus indicus l. Asclepiadaceae roots was found to inhibit lipid peroxidation and scavenge. The aim of the article is to investigate the antiarthritic efficacy of hemidesmus indicus in vitro. Hemidesmus indicus indian sarsaparilla shrub at simhachalam hill. Pharmacognosy and ethnopharmacology division, national botanical research institute, lucknowuttarpradesh, india the antioxidant and antihepatotoxic activities of 50% aqueous ethanolic extract of hemidesmus indicus r. Hemidesmus indicus root by pharmacognostically as per who guidelines. Shobha m, bharathi tr, sampath kumara kk and prakash hs abstract the roots of hemidesmus indicus are known to have bioactive properties.
Hemidesmus indicus protects against ethanolinduced liver. Indian journal of leprosy fruit two straight slender narrowly cylindrical widely divergent follicles. Jul 15, 2014 take the roots of hemidesmus indicus, rub on stone. In vitro antioxidant and antithrombotic activity of hemidesmus indicus l r. Although other species of this variety has been reported for its standards7 this has been the complete. Modulation of biochemical parameters by hemidesmus indicus in cumene hydroperoxideinduced murine skin.
Hemidesmus indicus is an indigenous ayurvedic medicinal plant used in soft drinks in india. Anantmool means the eternal root as the root of the plant spreads for a long way under the ground. The record derives from tropicos data supplied on 20120418 which reports it as an accepted name record 2609794 with original publication details. Buchanania axillaris, hemidesmus indicus, rhus mysorensis, phytochemical profile, antioxidant activity, anticholinesterase activity, antidiabetic activity background alzheimers disease ad is a chronic neurodegenerative irreversible brain disorder that affects daily living through memory loss and cognitive impairment 1, 2.
Determination of antimicrobial, cytotoxic and antioxidant. Hemidesmus indicus is a perennial, fastgrowing thin creeper vine that sends tendrils out at every node to cling to the surrounding vegetation for stability and support. This study was carried out to determine the chemoprotective potential of a polyherbal aqueous decoction comprised of nigella sativa seeds, hemidesmus indicus roots, and smilax glabra rhizome against bleomycin induced cytogenetic damage in human lymphocytes. Antiarthritis activity of roots of hemidesmus indicus r. Dietary changes play major risk roles in oxidative stress and cardiovascular disease and modulate normal metabolic function. Hemidesmus hemidesmus indicus root is regarded in ayurvedic medicine as a depurative and tonic. All these properties come in handy to purify the contamination of blood which is the principle behind many skin disorders and skin allergies. Hence, in the present study, the antiasthmatic activity of extract of roots of hemidesmus. Anantmul in rats alka mehta 1, neeraj k sethiya 1, chetan mehta 2, gb shah 3 1 pharmacy department, faculty of technology and engineering kalabhavan, the m. The concentrations needed to scavenge hydroxyl and superoxide radicals were 73.
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